Feri Pribadi webdevelopers AKU Belajar: Cancer Therapy Selection

1 Februari 2013

Cancer Therapy Selection

Cancer Therapy Selection 


Category: ARTICLES, Info & Tips, Health & Beauty

Choosing a cancer drug is not easy, a lot of factors to consider such as type of cancer, and radiosensitivitas Kemosensitivitas cancer, body immunity and the ability of patients to receive the treatment that we give, side effects of therapy we give.Cancer Types For the purposes of the administration of chemotherapy, the cancer is divided into 2 types:1.KANKER Hemopoitik and limfopoitik.Limfopoitik hemopoitik cancer and is generally a systemic cancer. Included in this type of cancer is cancer of the blood (leukemia), malignant lymphoma and bone marrow (myeloma). The main therapy is kenker hematology chemotherapy, surgery and radiotherapy while as an adjuvant.2.Kanker solid (solid).Solid cancers can be local, and may spread to regional or systemic to other organs. In this type of cancer, including cancers beyond hematology. Primary therapy of cancer are surgery and or radiotherapy, whereas chemotherapy was only given as an adjuvant at an advanced stage.Sensitivity Cancer tumor sensitivity to anti-cancer drugs are not the same, so it is divided into 3 types:1. Sensitive chemosensitive: - leukemia - malignant lymphoma - myeloma - choriocharsinoma - radiosensitive testicular cancer: tumors that can be destroyed with a dose of 3500-6000 rads in 3-4 weeks - Malignant Lymphoma - Myeloma - Retinoblastoma - Seminoma - Basalioma - T1 laryngeal cancer2. Responsive Kemoresponsif: - Small Tumors - Tumors that grow quickly - tumor cell differentiation ugly Radioresponsif - cancer is a size medium, T2-T3 and can be destroyed with a dose of 6000-8000 rads in 3-4 weeks3. Resistant Kemoresisten: - Tumor great - slow-growing cancer - Cancer cells are well differentiated Example: brain cancer, fibrosarcoma, malignant melanoma radioresistant tumors can only be destroyed with a dose of 8,000 rads. Example: Malignant melanoma, adenocarcinoma, brain cancer, soft tissue sarcoma.Radiosensitivitas tumors depends on many factors, among others:a. Type of tumor histologyb. The degree of cell differentiationc. Large tumord. Tumor vascularizatione. Location of tumor topography Several types of drugs and circumstances that may increase the sensitivity of radiotherapy: Oxygenation, Hipertermi, levamisole, some sitostatika. The sensitivity of cancers to chemotherapy usually there from the beginning and can also arise in the course of cancer treatment.Resistance Against Chemotherapy Resistance to chemotherapy can occur due to the pharmacokinetics of the drug such as:a. Changes in absorption - variability in gastrointestinal absorption of drugs - The gastointestinal disease - Not taking medication as it should (non-compliance) - drug formulations that do not fitb. Distribution changes - Changes in drug binding to serum proteins - Changes in the distribution because other drugs that bind to serum proteinsc. Metabolic changes - changes that hold detoxification enzymes - Liver disease - There are other drugs that participated - Reducing drug conjugates with age d. Reduced excretion - liver disease - kidney disease by Dr. Heru Noviat ~ Herdata SpA.

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